489476 LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem

489476
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₁₅H₄₀Cl₄N₈ 927019-63-4

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489476-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
      Catalogue Number489476
      Brand Family Calbiochem®
      SynonymsBHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I, LSD Inhibitor I
      References
      ReferencesSharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
      Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
      Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.
      Product Information
      CAS number927019-63-4
      FormPale yellow to yellow solid
      Hill FormulaC₁₅H₄₀Cl₄N₈
      Chemical formulaC₁₅H₄₀Cl₄N₈
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      489476

      References

      Reference overview
      Sharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
      Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
      Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2011 RFH
      SynonymsBHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I, LSD Inhibitor I
      DescriptionA bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
      FormPale yellow to yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number927019-63-4
      Chemical formulaC₁₅H₄₀Cl₄N₈
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
      Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
      Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.