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508228 L- Buthionine Sulfoximine - CAS 83730-53-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: gamma-glutamylcysteine synthetase
508228
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
83730-53-4C₈H₁₈N₂O₃S

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      		 Glass bottle 100 mg
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      Description
      OverviewA cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).
      Catalogue Number508228
      Brand Family Calbiochem®
      References
      ReferencesFruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
      OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
      Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
      Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.
      Product Information
      CAS number83730-53-4
      FormWhite powder
      Hill FormulaC₈H₁₈N₂O₃S
      Chemical formulaC₈H₁₈N₂O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetgamma-glutamylcysteine synthetase
      Purity≥97% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      L- Buthionine Sulfoximine - CAS 83730-53-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Fruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
      OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
      Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
      Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2013 JSW
      DescriptionA cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29 µM in melanoma, breast, and ovarian tumor cells, respectively).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number83730-53-4
      Chemical formulaC₈H₁₈N₂O₃S
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFruehauf, J.P., et al. 1997. Pigment Cell Res. 10, 236.
      OʹDwyer, P.J., et al. 1996. J. Clin. Oncol.14, 249.
      Griffith, O. W., 1982. J. Biol. Chem. 257, 13704.
      Griffith, O. W., et al. 1979. J. Biol. Chem. 254, 7558.