505880 L-745,870 Trihydrochloride - CAS 158985-00-3 - Calbiochem

505880
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Key Specifications Table

Empirical FormulaCAS #
C₁₈H₁₉N₄Cl•3HCl 158985-00-3

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      Glass bottle 10 mg
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      Description
      OverviewSelective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4 nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
      Catalogue Number505880
      Brand Family Calbiochem®
      SynonymsDopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
      References
      ReferencesLi, H. et al., 2013. J. Neurosci. 33, 3135.
      Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
      Kulagowski, J. et al. 1996. J. Med. Chem. 39, 1941.
      Product Information
      CAS number158985-00-3
      FormOff-white solid
      Hill FormulaC₁₈H₁₉N₄Cl•3HCl
      Chemical formulaC₁₈H₁₉N₄Cl•3HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetD₄
      Primary Target K<sub>i</sub>0.4 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      L-745,870 Trihydrochloride - CAS 158985-00-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      L-745,870 Trihydrochloride - CAS 158985-00-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      505880

      References

      Reference overview
      Li, H. et al., 2013. J. Neurosci. 33, 3135.
      Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
      Kulagowski, J. et al. 1996. J. Med. Chem. 39, 1941.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2013 JSW
      SynonymsDopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
      DescriptionSelective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4 nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
      FormOff-white solid
      CAS number158985-00-3
      Chemical formulaC₁₈H₁₉N₄Cl•3HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLi, H. et al., 2013. J. Neurosci. 33, 3135.
      Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
      Kulagowski, J. et al. 1996. J. Med. Chem. 39, 1941.