Millipore Sigma Vibrant Logo

505879 L-741,626 - CAS 81226-60-0 - Calbiochem

505879
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₀H₂₁ClN₂O 81226-60-0

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
5.05879.0001
Retrieving availability...
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewSelective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
      Catalogue Number505879
      Brand Family Calbiochem®
      SynonymsDopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626
      References
      ReferencesGrundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
      Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
      Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
      Product Information
      CAS number81226-60-0
      FormWhite solid
      Hill FormulaC₂₀H₂₁ClN₂O
      Chemical formulaC₂₀H₂₁ClN₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetD₂
      Primary Target K<sub>i</sub>7.1 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      L-741,626 - CAS 81226-60-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Grundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
      Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
      Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2013 JSW
      SynonymsDopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626
      DescriptionSelective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
      FormWhite solid
      CAS number81226-60-0
      Chemical formulaC₂₀H₂₁ClN₂O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGrundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
      Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
      Pillai, G. et al. 1998. Neuropharmacol. 337, 983.