533976 KLF10 Inhibitor, #48-15 - Calbiochem

533976
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₇H₁₆O₅

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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable salicylate compound that binds to the second zinc finger region of KLF10 and blocks its binding to DNA and also suppresses its transcriptional activity (IC50 = 40 µM). Shown to completely eliminate the induction of luciferase activity by exogenous KLF10 (~ 100 µM). Also represses the conversion of CD4+CD25- T cells to CD4+CD25+ T regulatory cells (by 59%) and diminishes Foxp3 expression (82% at 50 µM).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533976
      Brand Family Calbiochem®
      SynonymsKruppel-Like Factor 10 Inhibitor
      References
      ReferencesKhedkar, S.A., et al. 2015. J. Med. Chem. 58, 1466.
      Product Information
      FormWhite solid
      Hill FormulaC₁₇H₁₆O₅
      Chemical formulaC₁₇H₁₆O₅
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetKLF10
      Primary Target IC<sub>50</sub>40 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      KLF10 Inhibitor, #48-15 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Khedkar, S.A., et al. 2015. J. Med. Chem. 58, 1466.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-November-2015 JSW
      SynonymsKruppel-Like Factor 10 Inhibitor
      DescriptionA cell-permeable salicylate compound that binds to the second zinc finger region of KLF10 and blocks its binding to DNA and also suppresses its transcriptional activity (IC50 = 40 µM). Shown to completely eliminate the induction of luciferase activity by exogenous KLF10 (~ 100 µM). Also represses the conversion of CD4+CD25- T cells to CD4+CD25+ T regulatory cells (by 59%) and diminishes Foxp3 expression (82% at 50 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₆O₅
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKhedkar, S.A., et al. 2015. J. Med. Chem. 58, 1466.