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504479 JNJ 16259685 - CAS 409345-29-5 - Calbiochem

504479
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Key Specifications Table

Empirical FormulaCAS #
C₂₀H₂₃NO₃ 409345-29-5

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      Glass bottle 5 mg
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      Description
      OverviewAn extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34 nM; IC50 = 0.55 nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.
      Catalogue Number504479
      Brand Family Calbiochem®
      Synonyms(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
      References
      ReferencesLavreysen, H., et al. 2004. Neuropharmacology. 47, 961.
      Steckler, T., et al. 2005. Psychopharmacology. 179, 198.
      Steckler, T., et al. 2005. Behav. Brain. Res. 164, 52.
      Mabire, D., et al. 2005. J. Med. Chem. 48, 2134.
      Fukunaga, I., et al. 2007. Br. J. Pharmacol. 151, 870.
      Knopfel, T., et al. 2007. Br. J. Pharmacol. 151, 723.
      Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther. 343, 214.
      Product Information
      CAS number409345-29-5
      FormWhite to off-white solid
      Hill FormulaC₂₀H₂₃NO₃
      Chemical formulaC₂₀H₂₃NO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₁
      Primary Target IC<sub>50</sub>0.55 nM
      Primary Target K<sub>i</sub>0.34nM
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      JNJ 16259685 - CAS 409345-29-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Lavreysen, H., et al. 2004. Neuropharmacology. 47, 961.
      Steckler, T., et al. 2005. Psychopharmacology. 179, 198.
      Steckler, T., et al. 2005. Behav. Brain. Res. 164, 52.
      Mabire, D., et al. 2005. J. Med. Chem. 48, 2134.
      Fukunaga, I., et al. 2007. Br. J. Pharmacol. 151, 870.
      Knopfel, T., et al. 2007. Br. J. Pharmacol. 151, 723.
      Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther. 343, 214.

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-November-2017 JSW
      Synonyms(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
      DescriptionAn extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34 nM; IC50 = 0.55 nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.
      FormWhite to off-white solid
      CAS number409345-29-5
      Chemical formulaC₂₀H₂₃NO₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (25 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLavreysen, H., et al. 2004. Neuropharmacology. 47, 961.
      Steckler, T., et al. 2005. Psychopharmacology. 179, 198.
      Steckler, T., et al. 2005. Behav. Brain. Res. 164, 52.
      Mabire, D., et al. 2005. J. Med. Chem. 48, 2134.
      Fukunaga, I., et al. 2007. Br. J. Pharmacol. 151, 870.
      Knopfel, T., et al. 2007. Br. J. Pharmacol. 151, 723.
      Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther. 343, 214.