407700 Interleukin-10, Human, Recombinant, S. frugiperda

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407700
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407700-5UG
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      Plastic ampoule 5 μg
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      Description
      OverviewRecombinant, human interleukin-10 expressed in S. frugiperda insect cells. Pleiotropic cytokine that can exert either immunosuppressive or immunostimulatory effects on a variety of cell types. Potent modulator of monocyte/macrophage function. Exhibits anti-inflammatory effects by suppressing macrophage proliferation. Blocks lipopolysaccharide induction of MMP-2 and MMP-9. Known to reduce neuronal degeneration following CNS injury by blocking glutamate-induced caspase-3 activation. Human IL-10 is also active on murine cell lines.
      Catalogue Number407700
      Brand Family Calbiochem®
      SynonymsrhIL-1αrhIL-1βrhIL-10
      References
      ReferencesBachis, A., et al. 2001. J. Neurosci. 21, 3104.
      Fortunato, S.J., et al. 2001. Obstet. Gynecol. 98, 284.
      Fleming, S.D., et al. 1996. J. Immunol. 156, 1143.
      Wang, C.Q., et al. 1996. J. Cell Physiol. 166, 305.
      Niro, H., et al. 1994. Int. Immunol. 6, 661.
      Moore, K., et al. 1993. Annu. Rev. Immunol. 11, 165.
      Vieira, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 1172.
      Product Information
      FormLyophilized
      FormulationCarrier-free.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀ = 0.2-1 ng/ml as measured in a cell proliferation assay using a mouse mast cell line, MC/9.
      Purity≥95% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: <100 pg/μg IL-10
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze -70°C. Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Interleukin-10, Human, Recombinant, S. frugiperda SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-10, Human, Recombinant, S. frugiperda Certificates of Analysis

      TitleLot Number
      407700

      References

      Reference overview
      Bachis, A., et al. 2001. J. Neurosci. 21, 3104.
      Fortunato, S.J., et al. 2001. Obstet. Gynecol. 98, 284.
      Fleming, S.D., et al. 1996. J. Immunol. 156, 1143.
      Wang, C.Q., et al. 1996. J. Cell Physiol. 166, 305.
      Niro, H., et al. 1994. Int. Immunol. 6, 661.
      Moore, K., et al. 1993. Annu. Rev. Immunol. 11, 165.
      Vieira, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 1172.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-July-2008 RFH
      SynonymsrhIL-1αrhIL-1βrhIL-10
      DescriptionRecombinant, human interleukin-10 expressed in S. frugiperda insect cells. Pleiotropic cytokine that can exert either immunosuppressive or immunostimulatory effects on a variety of cell types. Potent modulator of monocyte/macrophage function. Exhibits anti-inflammatory effects by suppressing macrophage proliferation. Human IL-10 has cross-species reactivity and is active in mouse cell lines.
      FormLyophilized
      FormulationCarrier-free.
      Purity≥95% by SDS-PAGE
      ContaminantsEndotoxin: <100 pg/μg IL-10
      Biological activityED₅₀ = 0.2-1 ng/ml as measured in a cell proliferation assay using a mouse mast cell line, MC/9.
      SolubilityReconstitute in sterile water or buffer to a final concentration of 0.1-1 mg/ml as stock solution. Further dilute in buffer such as PBS, 1% BSA.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze -70°C. Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesBachis, A., et al. 2001. J. Neurosci. 21, 3104.
      Fortunato, S.J., et al. 2001. Obstet. Gynecol. 98, 284.
      Fleming, S.D., et al. 1996. J. Immunol. 156, 1143.
      Wang, C.Q., et al. 1996. J. Cell Physiol. 166, 305.
      Niro, H., et al. 1994. Int. Immunol. 6, 661.
      Moore, K., et al. 1993. Annu. Rev. Immunol. 11, 165.
      Vieira, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 1172.