407601 Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₀H₂₁N₅O₄ 509093-47-4

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407601-5MG
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      Description
      OverviewA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602).
      Catalogue Number407601
      Brand Family Calbiochem®
      SynonymsN-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, IRAK-1/4 Inhibitor
      References
      ReferencesBhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
      Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
      Product Information
      CAS number509093-47-4
      ATP CompetitiveN
      FormYellow crystalline solid
      Hill FormulaC₂₀H₂₁N₅O₄
      Chemical formulaC₂₀H₂₁N₅O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInterleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor, CAS 509093-47-4, is a cell-permeable, potent and selective inhibitor of IRAK-1 (IC50 = 300 nM) and IRAK-4 (IC50 = 200 nM).
      Biological Information
      Primary TargetInterleukin-1 receptor-associated kinases
      Primary Target IC<sub>50</sub>300 nM and 200 nM for IRAK-1 and -4
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      407601

      References

      Reference overview
      Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
      Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.

      Brochure

      Title
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-November-2012 JSW
      SynonymsN-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, IRAK-1/4 Inhibitor
      DescriptionA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src.
      FormYellow crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number509093-47-4
      Chemical formulaC₂₀H₂₁N₅O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesBhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
      Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.