Product Information
Applications
Biological Information
Primary TargetInhA
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InhA Inhibitor, NITD-916 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Manjunatha, U., et al. 2015. Sci. Trans. Med. 7, 269.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-August-2017 JSW
Synonyms6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one , Enoyl-acyl Carrier Protein Reductase Inhibitor, NITD-916, Enoyl-ACP reductase, NITD-916
DescriptionA cell-permeable, orally available, highly lipophilic 4-hydroxy-2-pyridone derivative that directly binds to the enoyl-substrate binding pocket of Mycobaterial enoyl reductase inhA in an NADH-dependent manner and inhibits its activity (IC50 = 570 nM). Shown to be about 5 to 8 times more potent ((MIC50 = 40 to 160 nM in multi-drug resistant strains of Mycobacterium) than isoniazid (MIC50 = 330 nM) and PA-824 (MIC50 = 400 nM). Exhibits in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. Exhibits low to moderate metabolic clearance in mouse and human hepatic microsomes. Suggested to inhibit the fatty acid elongation step that blocks the biosynthesis of mycolic acids and weakens the cell wall mycolyl-arabinogalactan-peptidoglycan complex, and ultimately lysis of Mycobacterium.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₂₅NO₂
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesManjunatha, U., et al. 2015. Sci. Trans. Med. 7, 269.

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Categories

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Antibiotics > Antiviral Agents