584223 InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₉H₁₆N₂O₆ • 2H₂O 18771-50-1

Pricing & Availability

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584223-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
      Catalogue Number584223
      Brand Family Calbiochem®
      SynonymsTHU, H4U, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate
      References
      ReferencesYusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
      Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857.
      Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7.
      Riva, C., et al. 1992. Chemotherapy 38, 358.
      Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
      Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720.
      Product Information
      CAS number18771-50-1
      FormLiquid
      FormulationA 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.
      Hill FormulaC₉H₁₆N₂O₆ • 2H₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcytidine deaminase
      Purity≥90% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      584223

      References

      Reference overview
      Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
      Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857.
      Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7.
      Riva, C., et al. 1992. Chemotherapy 38, 358.
      Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
      Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-January-2019 JSW
      SynonymsTHU, H4U, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate
      DescriptionA potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
      FormLiquid
      FormulationA 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number18771-50-1
      Structure formulaStructure formula
      Purity≥90% by TLC
      Storage ≤ -70°C
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Toxicity Standard Handling
      ReferencesYusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
      Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857.
      Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7.
      Riva, C., et al. 1992. Chemotherapy 38, 358.
      Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
      Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720.