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559292 InSolution™ RSK Inhibitor, SL0101 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₅H₂₄O₁₂

Pricing & Availability

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559292-500UG
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      Glass bottle 500 μg
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      Description
      OverviewA cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. The solid form (Cat. No. 559285) is also available.
      Catalogue Number559292
      Brand Family Calbiochem®
      References
      ReferencesSmith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
      Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
      Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
      Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
      Smith, J.A., et al. 2005. Cancer Res. 65, 1027.
      Product Information
      FormLiquid
      FormulationA 10 mM (500 µg/97 µl) solution of RSK Inhibitor, SL0101 (Cat. No. 559285) in DMSO.
      Hill FormulaC₂₅H₂₄O₁₂
      Chemical formulaC₂₅H₂₄O₁₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ RSK Inhibitor, SL0101 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ RSK Inhibitor, SL0101 - Calbiochem Certificates of Analysis

      TitleLot Number
      559292

      References

      Reference overview
      Smith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
      Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
      Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
      Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
      Smith, J.A., et al. 2005. Cancer Res. 65, 1027.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-February-2012 RFH
      DescriptionA cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM.
      FormLiquid
      FormulationA 10 mM (500 µg/97 µl) solution of RSK Inhibitor, SL0101 (Cat. No. 559285) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅H₂₄O₁₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesSmith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
      Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
      Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
      Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
      Smith, J.A., et al. 2005. Cancer Res. 65, 1027.