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539161 InSolution™ Proteasome Inhibitor I - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₂H₅₀N₄O₈

Pricing & Availability

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539161-5MG
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      Plastic ampoule 5 mg
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      Description
      Catalogue Number539161
      Brand Family Calbiochem®
      SynonymsPSI
      References
      ReferencesGriscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308.
      Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
      Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
      Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539160) in DMSO.
      Hill FormulaC₃₂H₅₀N₄O₈
      Chemical formulaC₃₂H₅₀N₄O₈
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetchymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceZ-Ile-Glu(OtBu)-Ala-Leu-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Proteasome Inhibitor I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Proteasome Inhibitor I - Calbiochem Certificates of Analysis

      TitleLot Number
      539161

      References

      Reference overview
      Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308.
      Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
      Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
      Traenckner, E.B., et al. 1994. EMBO J. 13, 5433."

      Brochure

      Title
      In Solution!" Product Flyer
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-September-2008 RFH
      SynonymsPSI
      DescriptionCell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents NF-κB activation in response to TNFα and okadaic acid through inhibition of IκBα degradation, thereby interfering with induction of iNOS in macrophages.
      FormLiquid
      FormulationA 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539160) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₂H₅₀N₄O₈
      Peptide SequenceZ-Ile-Glu(OtBu)-Ala-Leu-CHO
      Purity≥90% by HPLC
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesGriscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308.
      Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
      Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578.
      Traenckner, E.B., et al. 1994. EMBO J. 13, 5433.