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529606 InSolution™ PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem

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529606-1MG
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      Description
      OverviewA cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase.
      Catalogue Number529606
      Brand Family Calbiochem®
      Synonyms4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
      References
      ReferencesIra, G., et al. 2004. Nature 431, 1011.
      Papa, F.R., et al. 2003. Science 302, 1533.
      Bishop, A.C., et al. 2000. Nature 407, 395.
      Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
      Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.
      Product Information
      CAS number221244-14-0
      FormLiquid
      FormulationA 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO.
      Hill FormulaC₂₀H₂₁N₅
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetmutant c-Fyn, v-src, Cadk2, CaMKIIa, c-Abl etc.,
      Primary Target IC<sub>50</sub>3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µ
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 36-45

      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      529606

      References

      Reference overview
      Ira, G., et al. 2004. Nature 431, 1011.
      Papa, F.R., et al. 2003. Science 302, 1533.
      Bishop, A.C., et al. 2000. Nature 407, 395.
      Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
      Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-March-2013 JSW
      Synonyms4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
      DescriptionA cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase.
      FormLiquid
      FormulationA 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number221244-14-0
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -70°C.
      Toxicity Irritant
      ReferencesIra, G., et al. 2004. Nature 431, 1011.
      Papa, F.R., et al. 2003. Science 302, 1533.
      Bishop, A.C., et al. 2000. Nature 407, 395.
      Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677.
      Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.