528151 InSolution™ PARP Inhibitor VIII, PJ34 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₇H₁₇N₃O₂ • HCl

Pricing & Availability

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528151-2MG
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      Glass bottle 2 mg
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      Description
      OverviewA water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528151) is also available.
      Catalogue Number528151
      Brand Family Calbiochem®
      SynonymsN-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl, 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl
      References
      ReferencesAbdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
      Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
      Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
      Product Information
      FormLiquid
      FormulationA 20 mM (2 mg/301 µL) solution of PARP Inhibitor VIII, PJ34 (Cat. No. 528150) in H₂O.
      Hill FormulaC₁₇H₁₇N₃O₂ • HCl
      Chemical formulaC₁₇H₁₇N₃O₂ • HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPARP
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Harmful
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ PARP Inhibitor VIII, PJ34 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ PARP Inhibitor VIII, PJ34 - Calbiochem Certificates of Analysis

      TitleLot Number
      528151

      References

      Reference overview
      Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
      Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
      Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-December-2012 JSW
      SynonymsN-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide, HCl, 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide, HCl
      DescriptionA water-soluble phenanthridinone derivative that acts as a potent anti-inflammatory agent and a reversible inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50 = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50 = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke. The solid form of this compound (Cat. No. 528150) is also available.
      FormLiquid
      FormulationA 20 mM (2 mg/301 µL) solution of PARP Inhibitor VIII, PJ34 (Cat. No. 528150) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₇N₃O₂ • HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage ≤ -70°C
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Toxicity Harmful
      ReferencesAbdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255.
      Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108.
      Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.