474788 InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₆H₄₁N₃O₅

Pricing & Availability

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474788-10MG
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      Glass bottle 10 mg
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      Description
      OverviewPotent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.
      Catalogue Number474788
      Brand Family Calbiochem®
      SynonymsProteasome Inhibitor XI
      Application Data
      References
      ReferencesSteinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
      Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
      Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
      Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
      Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
      Wiertz, E.J., et al. 1996. Cell 84, 769.
      Jensen, T.J., et al. 1995. Cell 83, 129.
      Read, M.A., et al. 1995. Immunity 2, 493.
      Rock, K.L., et al. 1994. Cell 78, 761.
      Product Information
      FormLiquid
      FormulationA 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.
      Hill FormulaC₂₆H₄₁N₃O₅
      Chemical formulaC₂₆H₄₁N₃O₅
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target K<sub>i</sub>Ki = 4 nM for proteasomal inhibition
      Secondary targetIKK
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Leu-Leu-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 11-22

      Highly flammable.
      Harmful if swallowed.
      S PhraseS: 16-7

      Keep away from sources of ignition - No Smoking.
      Keep container tightly closed.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initital thaw, aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem Certificates of Analysis

      TitleLot Number
      474788

      References

      Reference overview
      Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
      Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
      Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
      Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
      Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
      Wiertz, E.J., et al. 1996. Cell 84, 769.
      Jensen, T.J., et al. 1995. Cell 83, 129.
      Read, M.A., et al. 1995. Immunity 2, 493.
      Rock, K.L., et al. 1994. Cell 78, 761.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-March-2012 JSW
      SynonymsProteasome Inhibitor XI
      Application Data
      DescriptionPotent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) is also available.
      FormLiquid
      FormulationA 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₆H₄₁N₃O₅
      Peptide SequenceZ-Leu-Leu-Leu-CHO
      Purity≥95% by HPLC
      Storage ≤ -70°C
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initital thaw, aliquot and freeze (-70°C).
      Toxicity Flammable
      ReferencesSteinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
      Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
      Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
      Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
      Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
      Wiertz, E.J., et al. 1996. Cell 84, 769.
      Jensen, T.J., et al. 1995. Cell 83, 129.
      Read, M.A., et al. 1995. Immunity 2, 493.
      Rock, K.L., et al. 1994. Cell 78, 761.