508315 InSolution™ KN-93 Phosphate in H₂O - Calbiochem

508315
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₆H₂₉ClN₂O₄S • H₃PO₄

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      Glass bottle 500 μg
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      Description
      Catalogue Number508315
      Brand Family Calbiochem®
      Synonyms2-(N-(2-Hydroxyethyl))-N-(4-methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), Phosphate, (E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide, Phosphate
      References
      ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      Product Information
      FormLiquid
      FormulationA 5 mM (500 µg/167 µL) sterile-filtered solution of KN-93 Phosphate (Cat. No. 422711) in H₂O.
      Hill FormulaC₂₆H₂₉ClN₂O₄S • H₃PO₄
      Chemical formulaC₂₆H₂₉ClN₂O₄S • H₃PO₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCaM kinase II
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ KN-93 Phosphate in H₂O - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-December-2013 JSW
      Synonyms2-(N-(2-Hydroxyethyl))-N-(4-methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), Phosphate, (E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide, Phosphate
      DescriptionA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
      FormLiquid
      FormulationA 5 mM (500 µg/167 µL) sterile-filtered solution of KN-93 Phosphate (Cat. No. 422711) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₆H₂₉ClN₂O₄S • H₃PO₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage ≤ -70°C
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.