344096 InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₄H₂₅FNNaO₄ 93957-55-2

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344096-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.
      Catalogue Number344096
      Brand Family Calbiochem®
      Synonyms(±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium
      References
      ReferencesYamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
      Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
      Ikeda, U., et al. 2000. Hypertension 36, 325.
      Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
      Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
      Yuan, J., et al. 1991. Atherosclerosis 87, 147.
      Product Information
      CAS number93957-55-2
      FormLiquid
      FormulationA 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O.
      Hill FormulaC₂₄H₂₅FNNaO₄
      Chemical formulaC₂₄H₂₅FNNaO₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHMG-CoA reductase
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Yamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
      Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
      Ikeda, U., et al. 2000. Hypertension 36, 325.
      Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
      Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
      Yuan, J., et al. 1991. Atherosclerosis 87, 147.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2013 JSW
      Synonyms(±)-(3Rʹ,5Sʹ,6E)-7-(3-(4-Fluorophenyl)-1-isopropylindol-2-yl)-3,5-dihydroxy-6-heptenoate, sodium
      DescriptionA synthetic, competitive inhibitor of HMG-CoA reductase that acts as anti-hypercholesterolemic agent. Unlike Lovastatin (Cat. No. 438185), Mevastatin (Cat. No. 474700), and Simvastatin (Cat. No. 567020), it does not require activation prior to use for in vitro studies. Reduces the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Fluvastatin is metabolized in the liver, primarily via hydroxylation of the indole ring at the 5- and 6-positions. N-Dealkylation and β-oxidation of the side-chain also occurs. The hydroxy metabolites are also reported to have some pharmacologic activity.
      FormLiquid
      FormulationA 10 mM (10 mg/2.13 ml) solution of Fluvastatin, Sodium Salt (344095) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number93957-55-2
      Chemical formulaC₂₄H₂₅FNNaO₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage ≤ -70°C
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Toxicity Standard Handling
      ReferencesYamamoto, A., et al. 2001. J. Pharm. Pharmacol. 53, 227.
      Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol. 52, 145.
      Ikeda, U., et al. 2000. Hypertension 36, 325.
      Levy, R.I., et al. 1993. Circulation 87 (4 Suppl.), III45.
      Tse, F.L.S. et al. 1992. J. Clin. Pharmacol. 32, 630.
      Yuan, J., et al. 1991. Atherosclerosis 87, 147.