220491 InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₀H₁₄ClN₃O₂ 516480-79-8

Pricing & Availability

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220491-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. The solid form of this compound (Cat. No. 220486) is also available.
      Catalogue Number220491
      Brand Family Calbiochem®
      Synonyms2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
      References
      ReferencesArienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.
      Product Information
      CAS number516480-79-8
      FormLiquid
      FormulationSupplied as a 25 mM (5 mg/550 µL) solution of Chk2 Inhibitor II (Cat. No. 220486) in DMSO.
      Hill FormulaC₂₀H₁₄ClN₃O₂
      Chemical formulaC₂₀H₁₄ClN₃O₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      220491

      References

      Reference overview
      Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-June-2012 JSW
      Synonyms2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
      DescriptionA cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. The solid form of this compound (Cat. No. 220486) is also available.
      FormLiquid
      FormulationSupplied as a 25 mM (5 mg/550 µL) solution of Chk2 Inhibitor II (Cat. No. 220486) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number516480-79-8
      Chemical formulaC₂₀H₁₄ClN₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage -20°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesArienti, K. L., et al. 2005. J. Med. Chem. 48, 1873.