219674 InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₈H₁₀F₃NO₃S₂ 307510-92-5

Pricing & Availability

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219674-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. The solid form of this compound (Cat. No. 219670) is also available.
      Catalogue Number219674
      Brand Family Calbiochem®
      Synonyms(Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTRinh-172 in DMSO, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone
      References
      ReferencesYang, H., et al. 2003. J. Biol. Chem. 278, 35079.
      Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
      Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
      Product Information
      CAS number307510-92-5
      FormLiquid
      FormulationA 50 mM (5 mg/244 µL) solution of CFTR Inhibitor-172 (Cat. No. 219670) in DMSO.
      Hill FormulaC₁₈H₁₀F₃NO₃S₂
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCFTR ion-channel
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36/37/39

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (70°C). Aliquots are stable for up to 3 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      219674

      References

      Reference overview
      Yang, H., et al. 2003. J. Biol. Chem. 278, 35079.
      Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
      Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-December-2012 JSW
      Synonyms(Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTRinh-172 in DMSO, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone
      DescriptionA cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. The solid form of this compound (Cat. No. 219670) is also available.
      FormLiquid
      FormulationA 50 mM (5 mg/244 µL) solution of CFTR Inhibitor-172 (Cat. No. 219670) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number307510-92-5
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (70°C). Aliquots are stable for up to 3 months at -70°C.
      Toxicity Irritant
      ReferencesYang, H., et al. 2003. J. Biol. Chem. 278, 35079.
      Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
      Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.