219674 Sigma-AldrichInSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
The InSolution™ CFTR Inhibitor-172, also referenced under CAS 307510-92-5, controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Biochemicals applications.
More>> The InSolution™ CFTR Inhibitor-172, also referenced under CAS 307510-92-5, controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Biochemicals applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTRinh-172 in DMSO, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone
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Overview
| Replacement Information |
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Key Specifications Table
| CAS # | Empirical Formula |
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| 307510-92-5 | C₁₈H₁₀F₃NO₃S₂ |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 219674-5MG |
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Glass bottle | 5 mg |
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| Description | |
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| Overview | A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. The solid form of this compound (Cat. No. 219670) is also available. |
| Catalogue Number | 219674 |
| Brand Family | Calbiochem® |
| Synonyms | (Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTRinh-172 in DMSO, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone |
| References | |
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| References | Yang, H., et al. 2003. J. Biol. Chem. 278, 35079. Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599. Ma, T., et al. 2002. J. Clin. Invest. 110, 1651. |
| Product Information | |
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| CAS number | 307510-92-5 |
| Form | Liquid |
| Formulation | A 50 mM (5 mg/244 µL) solution of CFTR Inhibitor-172 (Cat. No. 219670) in DMSO. |
| Hill Formula | C₁₈H₁₀F₃NO₃S₂ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | CFTR ion-channel |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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Documentation
InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem SDS
| Title |
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InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 219674 |
References
| Reference overview |
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| Yang, H., et al. 2003. J. Biol. Chem. 278, 35079. Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599. Ma, T., et al. 2002. J. Clin. Invest. 110, 1651. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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