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658548 InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
175178-82-2C₁₆H₁₄ClN₃O₂

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658548-1MG
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      Plastic ampoule 1 mg
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      Description
      Catalogue Number658548
      Brand Family Calbiochem®
      References
      ReferencesLevitski, A., and Gazit, A. 1995. Science 267, 1782.
      Fry, D.W., et al. 1994. Science 265, 1093.
      Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
      Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.
      Product Information
      CAS number175178-82-2
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
      FormClear to faint tan liquid
      FormulationA 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.
      Hill FormulaC₁₆H₁₄ClN₃O₂
      Chemical formulaC₁₆H₁₄ClN₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEpidermal growth factor receptor kinase
      Primary Target IC<sub>50</sub>3 nM against of epidermal growth factor receptor kinase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      658548

      References

      Reference overview
      Levitski, A., and Gazit, A. 1995. Science 267, 1782.
      Fry, D.W., et al. 1994. Science 265, 1093.
      Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
      Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

      Brochure

      Title
      In Solution!" Product Flyer

      Citations

      Title
    • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.
    • Ying-Hong Feng, et al. (2005) Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein-Independent Signals. Hypertension 46, 419-423.
    • Diane Gesty-Palmer, et al. (2005) b-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. Journal of Biological Chemistry 280, 32157-32167.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-September-2008 RFH
      DescriptionHighly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50 > 100 µM), the platelet-derived growth factor (PDGF) receptor (IC50 > 100 µM), and p210Bcr-Abl (IC50 >50 µM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.
      FormClear to faint tan liquid
      FormulationA 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number175178-82-2
      Chemical formulaC₁₆H₁₄ClN₃O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesLevitski, A., and Gazit, A. 1995. Science 267, 1782.
      Fry, D.W., et al. 1994. Science 265, 1093.
      Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
      Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.
      Citation
    • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.
    • Ying-Hong Feng, et al. (2005) Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein-Independent Signals. Hypertension 46, 419-423.
    • Diane Gesty-Palmer, et al. (2005) b-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. Journal of Biological Chemistry 280, 32157-32167.