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401020 Imiquimod - CAS 99011-02-6 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₄H₁₆N₄ 99011-02-6

Pricing & Availability

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401020-250MG
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      Plastic ampoule 250 mg
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      Description
      OverviewAn imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. Reported to bind to the cell surface receptor, TLR7 (toll-like receptor 7), and induce the secretion of several pro-inflammatory cytokines and chemokines both in vitro and in vivo.
      Catalogue Number401020
      Brand Family Calbiochem®
      Synonyms1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
      References
      ReferencesMajewski, S., et al. 2005. Int. J. Dermatol. 44, 14.
      Gibson, S.J., et al. 2002. Cell. Immunol. 218, 74.
      Hemmi, H., et al. 2002. Nat. Immunol. 3, 196.
      Megyeri, K., et al. 1995. Mol. Cell. Biol. 15, 2207.
      Product Information
      CAS number99011-02-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₄H₁₆N₄
      Chemical formulaC₁₄H₁₆N₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTLR7 (toll-like receptor 7)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25-36/37/38

      Toxic if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Upon thawing, warming may be required to resolubilize precipitated product.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Imiquimod - CAS 99011-02-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Imiquimod - CAS 99011-02-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      401020

      References

      Reference overview
      Majewski, S., et al. 2005. Int. J. Dermatol. 44, 14.
      Gibson, S.J., et al. 2002. Cell. Immunol. 218, 74.
      Hemmi, H., et al. 2002. Nat. Immunol. 3, 196.
      Megyeri, K., et al. 1995. Mol. Cell. Biol. 15, 2207.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-May-2009 JSW
      Synonyms1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
      DescriptionAn imidazoquinoline compound that acts as a potent immunomodulator and displays anti-angiogenic, anti-viral and anti-inflammatory properties. Reported to bind to the cell surface receptor, TLR7 (toll-like receptor 7), and induce the secretion of several pro-inflammatory cytokines and chemokines both in vitro and in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number99011-02-6
      Chemical formulaC₁₄H₁₆N₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (3 mg/ml); warming to 60°C is required for complete solubilization.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Upon thawing, warming may be required to resolubilize precipitated product.
      Toxicity Toxic
      ReferencesMajewski, S., et al. 2005. Int. J. Dermatol. 44, 14.
      Gibson, S.J., et al. 2002. Cell. Immunol. 218, 74.
      Hemmi, H., et al. 2002. Nat. Immunol. 3, 196.
      Megyeri, K., et al. 1995. Mol. Cell. Biol. 15, 2207.