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420326 IRTK Activator III, DDN - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₄H₈Cl₂O₆

Pricing & Availability

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420326-25MG
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      Glass bottle 25 mg
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      Description
      OverviewAn orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5 µM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20 mg/kg, p.o.).
      Catalogue Number420326
      Brand Family Calbiochem®
      Synonyms5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone
      References
      ReferencesHe, K., et al. 2011. J. Biol. Chem. 286, 37379.
      Product Information
      FormPale yellow-green powder
      Hill FormulaC₁₄H₈Cl₂O₆
      Chemical formulaC₁₄H₈Cl₂O₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      IRTK Activator III, DDN - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      IRTK Activator III, DDN - Calbiochem Certificates of Analysis

      TitleLot Number
      420326

      References

      Reference overview
      He, K., et al. 2011. J. Biol. Chem. 286, 37379.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2012 JSW
      Synonyms5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone
      DescriptionAn orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5 µM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20 mg/kg, p.o.).
      FormPale yellow-green powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₈Cl₂O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHe, K., et al. 2011. J. Biol. Chem. 286, 37379.