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14-599 IRAK4 Protein, active, 10 µg

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10 µg  Also available in 250 µg size --call for pricing and availability and reference catalog number 14-599M when ordering the 250 µg size.
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      Replacement Information
      Catalogue Number14-599
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionIRAK4 Protein, active, 10 µg
      OverviewN-terminal His6-tagged, recombinant full length, human IRAK4
      Product Information
      Quality LevelMQ100
      ApplicationActive, N-terminal His6-tagged, recombinant full length, human IRAK4, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryInterleukin-1 receptor (see IL1R; MIM 147810)-associated kinases (e.g., IRAK1; MIM 300283) are important mediators in the signal transduction of Toll-like receptor (TLR, e.g., TLR4; MIM 603030) and IL1R family members, collectively referred to as TIRs. IRAK4 functions in this signal transduction pathway.[supplied by OMIM]
      Gene Symbol
      • IRAK4
      • NY-REN-64
      • REN64
      • IRAK-4
      • LOC51135
      • IPD1
      Protein TargetIRAK4
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTKL
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NWZ3 # Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up- regulation and mRNA stabilization. Phosphorylates IRAK1.
      COFACTOR: Magnesium.
      SIZE: 460 amino acids; 51530 Da
      SUBUNIT: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.
      DISEASE: SwissProt: Q9NWZ3 # Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. & Defects in IRAK4 are the cause of IRAK4 deficiency [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
      SIMILARITY: SwissProt: Q9NWZ3 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 death domain. & Contains 1 protein kinase domain.
      Molecular Weight57.1kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of MBP (Catalog #13-104)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250 µg size --call for pricing and availability and reference catalog number 14-599M when ordering the 250 µg size.
      Transport Information
      Supplemental Information

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      Alternative Packsize

      Catalog Number Description  
      14-599M IRAK4 Protein, active, 250 µg Show Pricing & Availability

      Product Families


      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases