407616 IL-1R Antagonist - CAS 566914-00-9 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₈H₂₆N₂O₂ 566914-00-9

Pricing & Availability

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407616-10MG
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      Plastic ampoule 10 mg
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      407616-25MG
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          Description
          OverviewA cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
          Catalogue Number407616
          Brand Family Calbiochem®
          SynonymsBB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
          References
          ReferencesBartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.
          Product Information
          CAS number566914-00-9
          ATP CompetitiveN
          FormColorless oil
          Hill FormulaC₁₈H₂₆N₂O₂
          Chemical formulaC₁₈H₂₆N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationIL-1R Antagonist, CAS 566914-00-9, is a cell-permeable, end protected L-valyl derivative. Specifically blocks TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction.
          Biological Information
          Primary TargetTIR domain-mediated MyD88/IL1-RI interaction
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          IL-1R Antagonist - CAS 566914-00-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          IL-1R Antagonist - CAS 566914-00-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          407616

          References

          Reference overview
          Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2008 RFH
          SynonymsBB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
          DescriptionA cell-permeable, end protected L-valyl derivative of the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
          FormColorless oil
          Intert gas (Yes/No) Packaged under inert gas
          CAS number566914-00-9
          Chemical formulaC₁₈H₂₆N₂O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.