401479 IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₉H₈N₂OS₂ 354812-17-2

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401479-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 = ~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF. A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401485) in DMSO is also available.
      Catalogue Number401479
      Brand Family Calbiochem®
      SynonymsSC-514
      References
      ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
      Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
      Product Information
      CAS number354812-17-2
      ATP CompetitiveY
      FormPale yellow solid
      Hill FormulaC₉H₈N₂OS₂
      Chemical formulaC₉H₈N₂OS₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIKK-2
      Primary Target IC<sub>50</sub>3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      401479

      References

      Reference overview
      Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
      Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsSC-514
      DescriptionA cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 >200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number354812-17-2
      Chemical formulaC₉H₈N₂OS₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
      Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.