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HCP-20K Human C-Peptide RIA

HCP-20K
250 tubes  
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      Overview

      Replacement Information

      Key Specifications Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      C-Peptide H RIA Radioactive, 125I
      Description
      Catalogue NumberHCP-20K
      DescriptionHuman C-Peptide RIA
      Background InformationC-peptide is a byproduct of normal insulin production by the beta cells in the pancreas and correlates directly to endogenous concentrations of insulin.
      References
      Product Information
      Detection methodRadioactive 125I
      Performance
      • ED80 = 0.3 ± 0.1 ng/mL
        ED50 = 1.1 ± 0.1 ng/mL
        ED20 = 4.1 ± 0.4 ng/mL
      Quality LevelMQ100
      Applications
      ApplicationThis radioimmunoassay (RIA) measures & quantifies C-Peptide for use in Metabolism & Endocrine research.
      Key Applications
      • Radioimmunoassay
      Application NotesOvernight, equilibrium incubation at 4°C. Sample volume < 100 μL serum, plasma, or tissue culture media.
      Biological Information
      Species Reactivity
      • Human
      Analytes Available
      • C-Peptide
      Entrez Gene Number
      Entrez Gene SummaryAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
      Gene Symbol
      • INS
      • proinsulin
      • insulin
      Radioactive Isotype125I-Human C-Peptide
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SIZE: 110 amino acids; 11981 Da
      SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
      Physicochemical Information
      Sensitivity
      • 0.1 ng/mL
      Standard Curve Range
      • 0.1–5 ng/mL
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size250 tubes
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Protocols

      Title
      Human C-Peptide

      Human C-Peptide RIA SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overviewPub Med ID
      Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients.
      V T T Huyen,D V Phan,P Thang,P T Ky,N K Hoa,C G Ostenson
      Evidence-based complementary and alternative medicine : eCAM  2012  2012

      Show Abstract
      23125867 23125867
      Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): association with clinical characteristics, beta cell function and cardio-metabolic risk factors.
      A C Thai,V Mohan,B A K Khalid,C S Cockram,C Y Pan,P Zimmet,J P Yeo,
      Diabetes research and clinical practice  80  2008

      Show Abstract
      18207602 18207602
      Sensitive quantitative analysis of C-peptide in human plasma by 2-dimensional liquid chromatography-mass spectrometry isotope-dilution assay.
      Eduard Rogatsky, Beate Balent, Gayotri Goswami, Vlad Tomuta, Harsha Jayatillake, Greg Cruikshank, Louis Vele, Daniel T Stein
      Clinical chemistry  52  872-9  2006

      Show Abstract
      16556683 16556683

      Brochure

      Title
      A closer look at immunoassay platforms. Beyond fit for purpse. Bring your biomarkers to life with EMD Millipore Immunoassay Platform Solutions (SigmaMillipore)
      ELISAs, RIAs & GyroMark HT Assays
      Protein Detection Platform and Services Brochure

      Technical Info

      Title
      Quality Control Ranges for Catalog # 6000-K Expected Ranges of Each Analyte Using EMD MILLIPORE RIA Kits as Listed Below

      Data Sheet

      Title
      Full Service Custom-built Assays (MilliporeSigma)

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      Categories

      Life Science Research > Protein Detection and Quantification > Immunoassays > Radioimmunoassay (RIA) > Complete RIA Kits
      Life Science Research > Antibodies and Assays > Immunoassays > Radioimmunoassay (RIA) > Complete RIA Kits