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373273 Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem

373273
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Empirical FormulaCAS #
C₂₆H₂₆ClN₃O₄ 329196-48-7

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373273-10MG
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      Description
      OverviewA nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 µM).
      Catalogue Number373273
      Brand Family Calbiochem®
      SynonymsN-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-tris(ethyloxy)benzamide, Smo Antagonist V
      References
      ReferencesRominger, C.M., et al. 2009. J. Pharmacol. Exp. Ther. 329, 995.
      Rohatgi, R., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 3196.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
      Product Information
      CAS number329196-48-7
      FormWhite powder
      Hill FormulaC₂₆H₂₆ClN₃O₄
      Chemical formulaC₂₆H₂₆ClN₃O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      373273

      References

      Reference overview
      Rominger, C.M., et al. 2009. J. Pharmacol. Exp. Ther. 329, 995.
      Rohatgi, R., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 3196.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsN-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-tris(ethyloxy)benzamide, Smo Antagonist V
      DescriptionA nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 µM).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number329196-48-7
      Chemical formulaC₂₆H₂₆ClN₃O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRominger, C.M., et al. 2009. J. Pharmacol. Exp. Ther. 329, 995.
      Rohatgi, R., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 3196.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.