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531470 HIV TAR Hairpin Binder - Calbiochem

531470
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₆H₁₂F₃N₃OS

Pricing & Availability

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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable, non-cytotoxic, non cationic thienopyridine compound that potently and dose-dependently inhibits HIV-mediated cytopathicity (EC50 = 28 µM in T lymphocytes) and displays antiviral properties. Shown to specifically bind and stabilize HIV transactivation response (TAR) element RNA hairpin motif (Kd = 2.4 µM) in a reversible manner without disrupting 5′ untranslated region (UTR).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531470
      Brand Family Calbiochem®
      Synonyms3-Amino-6-methyl-N-(3-(trifluoromethyl)phenyl)thieno[2,3-b]pyridine-2-carboxamide, (3-Amino-6-methylthiopheno[2,3-b]pyridin-2-yl)-N-(3-(trifluoromethyl)phenyl)carboxamide, HIV TAR Hairpin Stabilizer
      References
      ReferencesSztuba-Solinska, J., et al. 2014. J. Am. Chem. Soc. 136, 8402.
      Product Information
      FormYellow powder
      Hill FormulaC₁₆H₁₂F₃N₃OS
      Chemical formulaC₁₆H₁₂F₃N₃OS
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHIV transactivation response (TAR) element RNA
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      HIV TAR Hairpin Binder - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Sztuba-Solinska, J., et al. 2014. J. Am. Chem. Soc. 136, 8402.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-August-2014 JSW
      Synonyms3-Amino-6-methyl-N-(3-(trifluoromethyl)phenyl)thieno[2,3-b]pyridine-2-carboxamide, (3-Amino-6-methylthiopheno[2,3-b]pyridin-2-yl)-N-(3-(trifluoromethyl)phenyl)carboxamide, HIV TAR Hairpin Stabilizer
      DescriptionA cell-permeable, non-cationic thienopyridine compound that selectively targets HIV-1 transactivation response (TAR) hairpin motif (Kd = 2.4 µM), but not other structural elements in HIV-1 5′ untranslated region (UTR), via hydrophobic & aromatic type of interactions, reducing TAR conformational flexibility without affecting UTR dimerization. Shown to protect T-lymphoblastoid cell line CEM-SS against HIV-1-induced cytopathicity (% cell survival/[drug] in µM = 90%/550, 78%/167, 50%/28 in 6-d infected cultures by XTT) without conferring cytotoxicity in non-infected cultures even at concentrations as high as 550 µM.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₆H₁₂F₃N₃OS
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSztuba-Solinska, J., et al. 2014. J. Am. Chem. Soc. 136, 8402.