Product Information
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem Certificates of Analysis

TitleLot Number
400083

References

Reference overview
Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-December-2013 JSW
SynonymsCAY10585, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6
DescriptionA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
FormLight beige powder
Intert gas (Yes/No) Packaged under inert gas
CAS number934593-90-5
Chemical formulaC₂₆H₂₉NO₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
Lee, K., et al. 2007. J. Med. Chem. 50, 1675.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Hypoxia-Inducable Factor Inhibitors