371958 Sigma-AldrichH-8, Dihydrochloride
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases.
More>> A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases. Less<<Synonyms: N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I
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Overview
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Key Specifications Table
CAS # | Empirical Formula |
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113276-94-1 | C₁₂H₁₅N₃O₂S · 2HCl |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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371958-1MG |
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Plastic ampoule | 1 mg |
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Product Information | |
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CAS number | 113276-94-1 |
ATP Competitive | Y |
Form | Lyophilized |
Hill Formula | C₁₂H₁₅N₃O₂S · 2HCl |
Chemical formula | C₁₂H₁₅N₃O₂S · 2HCl |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | MLCK |
Primary Target K<sub>i</sub> | 68 µM against MLCK |
Purity | >95% by TLC |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Supplemental Information |
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Specifications |
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Global Trade Identification Number | |
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Catalog Number | GTIN |
371958-1MG | 4055977213508 |
Documentation
H-8, Dihydrochloride SDS
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H-8, Dihydrochloride Certificates of Analysis
Title | Lot Number |
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371958 |
References
Reference overview |
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Ido, M., et al. 1991. Br. J. Cancer 64, 1103. Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523. Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577. Hidaka, H., et al. 1984. Biochemistry 23, 5036. |