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371958 H-8, Dihydrochloride

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases.

H-8, Dihydrochloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I

Primary Target: MLCK
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371958
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
113276-94-1C₁₂H₁₅N₃O₂S · 2HCl

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      Description
      OverviewA potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits protein kinase A (Ki = 1.2 µM), myosin light chain kinase (Ki = 68 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).
      Catalogue Number371958
      Brand Family Calbiochem®
      SynonymsN-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I
      References
      ReferencesIdo, M., et al. 1991. Br. J. Cancer 64, 1103.
      Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
      Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
      Hidaka, H., et al. 1984. Biochemistry 23, 5036.
      Product Information
      CAS number113276-94-1
      ATP CompetitiveY
      FormLyophilized
      Hill FormulaC₁₂H₁₅N₃O₂S · 2HCl
      Chemical formulaC₁₂H₁₅N₃O₂S · 2HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMLCK
      Primary Target K<sub>i</sub>68 µM against MLCK
      Purity>95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      371958-1MG4055977213508

      Documentation

      H-8, Dihydrochloride SDS

      Title

      Safety Data Sheet (SDS) 

      H-8, Dihydrochloride Certificates of Analysis

      TitleLot Number
      371958

      References

      Reference overview
      Ido, M., et al. 1991. Br. J. Cancer 64, 1103.
      Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
      Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
      Hidaka, H., et al. 1984. Biochemistry 23, 5036.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-January-2010 RFH
      SynonymsN-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor I
      DescriptionA potent, cell-permeable, reversible, and ATP-competitive, and highly active inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits myosin light chain kinase (Ki = 68 µM), protein kinase A (Ki = 1.2 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).
      FormLyophilized
      CAS number113276-94-1
      Chemical formulaC₁₂H₁₅N₃O₂S · 2HCl
      Structure formulaStructure formula
      Purity>95% by TLC
      SolubilityH₂O (10 mg/ml). Further dilute with aqueous buffer just prior to use.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
      Toxicity Standard Handling
      ReferencesIdo, M., et al. 1991. Br. J. Cancer 64, 1103.
      Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523.
      Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577.
      Hidaka, H., et al. 1984. Biochemistry 23, 5036.