371818 G-Protein βγ Binding Peptide, mSIRK - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₉₃H₁₅₀N₂₀O₂₅

Pricing & Availability

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371818-1MG
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      Glass bottle 1 mg
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      371818-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC50 ~ 2.5 - 5 µM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca2+ release from internal stores. Negative control is also available (Cat. No. 371820).
          Catalogue Number371818
          Brand Family Calbiochem®
          SynonymsmSIRK, myr-SIRKALNILGYPDYD-OH
          References
          ReferencesGoubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
          Scott, J.K., et al. 2001. EMBO J. 20, 767.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₉₃H₁₅₀N₂₀O₂₅
          Chemical formulaC₉₃H₁₅₀N₂₀O₂₅
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetN-myristoylated G-protein βγ selective binding
          Primary Target IC<sub>50</sub>EC50 ~ 2.5 - 5 µM in activation of ERK1/2 in rat arterial smooth muscle and Rat2 cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceMyr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          G-Protein βγ Binding Peptide, mSIRK - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          G-Protein βγ Binding Peptide, mSIRK - Calbiochem Certificates of Analysis

          TitleLot Number
          371818

          References

          Reference overview
          Goubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
          Scott, J.K., et al. 2001. EMBO J. 20, 767.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-July-2008 RFH
          SynonymsmSIRK, myr-SIRKALNILGYPDYD-OH
          DescriptionA cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange. Reported to cause a rapid activation of ERK1/2 (EC50 ~2.5-5 µM) in RASM (rat arterial smooth muscle) and Rat2 cells. Promotes the phosphorylation of JNK and p38 MAP kinase. Also increases phospholipase C activity and causes Ca2+ release from internal stores.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉₃H₁₅₀N₂₀O₂₅
          Peptide SequenceMyr-N-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp-OH
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C
          Toxicity Standard Handling
          ReferencesGoubaeva, F., et al. 2003. J. Biol. Chem. 278, 19634.
          Scott, J.K., et al. 2001. EMBO J. 20, 767.