365251 Gö 6983 - CAS 133053-19-7 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₆H₂₆N₄O₃ 133053-19-7

Pricing & Availability

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365251-500UG
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      Plastic ampoule 500 μg
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      Description
      OverviewA potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
      Catalogue Number365251
      Brand Family Calbiochem®
      Synonyms2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
      References
      ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
      Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
      Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
      Product Information
      CAS number133053-19-7
      ATP CompetitiveY
      FormOrange red solid
      Hill FormulaC₂₆H₂₆N₄O₃
      Chemical formulaC₂₆H₂₆N₄O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationGö 6983, CAS 133053-19-7, is a potent, cell-permeable, reversible, and ATP-competitive inhibitor of several PKC isozymes (IC50 = 7 nM for PKCα & β; 6 nM for PKCγ; 10 nM for PKCδ; & 60 nM for PKCζ).
      Biological Information
      Primary TargetPKCα and PKCβ
      Primary Target IC<sub>50</sub>7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Gö 6983 - CAS 133053-19-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Gö 6983 - CAS 133053-19-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      365251

      References

      Reference overview
      Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
      Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
      Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.

      Brochure

      Title
      PKC Pathway Poster PDF ( 676 KB )

      Citations

      Title
    • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
    • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
    • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
    • Bai Luo, Stephen M. Prescott and Matthew K. Topham. (2003) Association of Diacylglycerol Kinase ζ with Protein Kinase C α: Spatial Regulation of Diacylglycerol Signaling. Journal of Cell Biology 160, 929-937.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-December-2015 JSW
      Synonyms2-[1-(3-Dimethylaminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide, Go 6983
      DescriptionA potent, cell-permeable, inhibitor of protein kinase C (PKC) that has been shown to selectively inhibit several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; 60 nM for PKCζ). Gö 6983 does not effectively inhibit PKCµ (IC50 = 20 µM) and can thus be used to differentiate PKCµ from other PKC isozymes.
      FormOrange red solid
      CAS number133053-19-7
      Chemical formulaC₂₆H₂₆N₄O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWang, D., et al. 1998. J. Biol. Chem. 273, 33027.
      Stempka, L., et al. 1997. J. Biol. Chem. 272, 6805.
      Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
      Citation
    • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
    • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
    • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
    • Bai Luo, Stephen M. Prescott and Matthew K. Topham. (2003) Association of Diacylglycerol Kinase ζ with Protein Kinase C α: Spatial Regulation of Diacylglycerol Signaling. Journal of Cell Biology 160, 929-937.