344930 Furin Inhibitor I - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₄H₆₆ClN₁₁O₅

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
344930-150MG
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      Plastic ampoule 150 mg
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      344930-1MG
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          Description
          OverviewA peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
          Catalogue Number344930
          Brand Family Calbiochem®
          SynonymsDecanoyl-RVKR-CMK
          References
          ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
          Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
          Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
          Garten, W., et al. 1994. Biochimie 76, 217.
          Hallenberger, S., et al. 1992. Nature 360, 358.
          Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
          Product Information
          FormOff-white solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₃₄H₆₆ClN₁₁O₅
          Chemical formulaC₃₄H₆₆ClN₁₁O₅
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetviral glycoproteins
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Furin Inhibitor I - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Furin Inhibitor I - Calbiochem Certificates of Analysis

          TitleLot Number
          344930

          References

          Reference overview
          Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
          Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
          Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
          Garten, W., et al. 1994. Biochimie 76, 217.
          Hallenberger, S., et al. 1992. Nature 360, 358.
          Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2008 RFH
          SynonymsDecanoyl-RVKR-CMK
          DescriptionA peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
          FormOff-white solid
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₃₄H₆₆ClN₁₁O₅
          Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO or Methanol (1 mg/ml)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
          Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
          Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
          Garten, W., et al. 1994. Biochimie 76, 217.
          Hallenberger, S., et al. 1992. Nature 360, 358.
          Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.