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344932 Furin, Human, Recombinant

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344932
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344932-50UL
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      Description
      OverviewRecombinant, human furin expressed in vaccinia virus (VV:hFUR713t) infected BSC-40 cells. Supplied as a crude preparation of soluble furin obtained from cytoplasmic extracts. Furin is a type I membrane protein that processes stromelysin-3 (MMP-11) and MT1-MMP. It cleaves pro-hormones, neuropeptide precursors, some viral proteins, and bacterial toxins.
      This preparation was subjected to UV irradiation for 5 min to inactivate any residual vaccinia virus.
      Catalogue Number344932
      Brand Family Calbiochem®
      References
      ReferencesBassi, D.E., et al. 2001. Mol. Carcinog. 31, 224.
      Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
      Creemers, J.W., et al. 2001. J. Biol. Chem. 276, 4211.
      Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
      Molloy, S.S., et al. 1992. J. Biol. Chem. 267, 16396.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of furin that will cleave 1.0 pmol AMC from the substrate pGlu-Arg-Thr-Lys-Arg-AMC per min at 30°C, pH 7.5.
      FormLiquid
      FormulationIn 20 mM Bis-Tris buffer, 1 mg/ml BSA, pH 7.0.
      Quality LevelMQ100
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Furin, Human, Recombinant SDS

      Title

      Safety Data Sheet (SDS) 

      Furin, Human, Recombinant Certificates of Analysis

      TitleLot Number
      344932

      References

      Reference overview
      Bassi, D.E., et al. 2001. Mol. Carcinog. 31, 224.
      Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
      Creemers, J.W., et al. 2001. J. Biol. Chem. 276, 4211.
      Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
      Molloy, S.S., et al. 1992. J. Biol. Chem. 267, 16396.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-January-2008 JSW
      DescriptionRecombinant, human furin expressed in vaccinia virus (VV:hFUR713t) infected BSC-40 cells. Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like pro-hormone convertase (PC) family. Members of this family cleave pro-hormones, neuropeptide precursors, some viral proteins, and bacterial toxins. The preparation was subjected to UV irradiation for 5 minutes to inactivate any residual virus.
      FormLiquid
      FormulationIn 20 mM Bis-Tris buffer, 1 mg/ml BSA, pH 7.0.
      Unit definitionOne unit is defined as the amount of furin that will cleave 1.0 pmol AMC from the substrate pGlu-Arg-Thr-Lys-Arg-AMC per min at 30°C, pH 7.5.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesBassi, D.E., et al. 2001. Mol. Carcinog. 31, 224.
      Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
      Creemers, J.W., et al. 2001. J. Biol. Chem. 276, 4211.
      Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
      Molloy, S.S., et al. 1992. J. Biol. Chem. 267, 16396.