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344850 Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem

A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC₅₀ = 100 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: FB₁

Primary Target: ceramide synthase
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344850
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
116355-83-0C₃₄H₅₉NO₁₅

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344850-1MG
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      Description
      OverviewA cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC50 = 100 nM). Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Exhibits carcinogenic properties.
      Catalogue Number344850
      Brand Family Calbiochem®
      SynonymsFB₁
      References
      ReferencesWu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
      Riley, R.T., et al. 1994. J. Nutr. 124, 594.
      Wolf, G. 1994. Nutr. Rev. 52, 246.
      Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
      Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
      Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
      Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
      Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.
      Product Information
      CAS number116355-83-0
      ATP CompetitiveN
      FormWhite to beige powder
      Hill FormulaC₃₄H₅₉NO₁₅
      Chemical formulaC₃₄H₅₉NO₁₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetceramide synthase
      Primary Target IC<sub>50</sub>100 nM against sphingosine N-acyltransferase (ceramide synthase)
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSTZ8350000
      Safety Information
      R PhraseR: 40

      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-26-36/37/39

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Fumonisin B₁, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      344850

      References

      Reference overview
      Wu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
      Riley, R.T., et al. 1994. J. Nutr. 124, 594.
      Wolf, G. 1994. Nutr. Rev. 52, 246.
      Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
      Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
      Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
      Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
      Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.

      Citations

      Title
    • Rita Fishelevich, et al. (2006) Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression during Terminal Differentiation. Journal of Immunology 176, 2590-2599.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-January-2017 JSW
      SynonymsFB₁
      DescriptionFumonisin B1 is a neurotoxin and a phytotoxin. A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase) (IC50 = 100 nM). Cellular effects also appear to be induced by micromolar levels of FB1. Because it inhibits ceramide synthase activity, it elevates cellular levels of sphingoid bases, including sphinganine, resulting in overall inhibition of sphingolipid biosynthesis. Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Has carcinogenic properties.
      FormWhite to beige powder
      CAS number116355-83-0
      RTECSTZ8350000
      Chemical formulaC₃₄H₅₉NO₁₅
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityMethanol (5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 4289
      ReferencesWu, W.I., et al. 1995. J. Biol. Chem. 270, 13171.
      Riley, R.T., et al. 1994. J. Nutr. 124, 594.
      Wolf, G. 1994. Nutr. Rev. 52, 246.
      Merrill, A.H. Jr., et al. 1993. Adv. Lipid Res. 26, 215.
      Merrill, Jr., A.H., et al. 1993. J. Biol. Chem. 268, 27299.
      Voss, K.A., et al. 1993. Nat. Toxins 1, 222.
      Wang, E., et al. 1991. J. Biol. Chem. 266, 14486.
      Harrison, L.R., et al. 1990. J. Vet. Diag. Invest. 2, 217.
      Citation
    • Rita Fishelevich, et al. (2006) Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression during Terminal Differentiation. Journal of Immunology 176, 2590-2599.
      		•