505991 Flumazenil - CAS 78755-81-4 - Calbiochem

Flumazenil - CAS 78755-81-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GABAA Receptor Antagonist, Flumazenil, Ro 15-1788

Primary Target: GABAA
505991
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₄FN₃O₃ 78755-81-4

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.05991.0001
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          		 Glass bottle 10 mg
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          Description
          OverviewA competitive blocker of benzodiazepine activation of inhibitory GABAergic synpases (ID50 = 200 µg/kg/i.p). Binds to the benzodiazepine site of GABAA receptors. Enhances GABAA-receptor mediated currents and antagonizes the enhancing effects of benzodiapine agonist flurazepam. Exhibits fast association and dissociation from the benzodiazepine binding site. Permeates the blood brain barrier, however, the level of uptake may depend on efflux effects of p-glycogprotein transporter.
          Catalogue Number505991
          Brand Family Calbiochem®
          SynonymsGABAA Receptor Antagonist, Flumazenil, Ro 15-1788
          References
          ReferencesFroklage, F.E., et al. 2012. EJNMMI Research. 2, 12.
          Li, J., et al. 2006. Neuropharmacol. 51, 168.
          Weiss, M., et al. 2002. Neurochem. Res. 27, 1605.
          Atack, J., et al. 1999. Neuropsychopharmacol. 20, 255.
          Votey, S.R., et al. 1991. Ann. Emerg. Med. 20, 181.
          Product Information
          CAS number78755-81-4
          FormWhite solid
          Hill FormulaC₁₅H₁₄FN₃O₃
          Chemical formulaC₁₅H₁₄FN₃O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGABAA
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Flumazenil - CAS 78755-81-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Froklage, F.E., et al. 2012. EJNMMI Research. 2, 12.
          Li, J., et al. 2006. Neuropharmacol. 51, 168.
          Weiss, M., et al. 2002. Neurochem. Res. 27, 1605.
          Atack, J., et al. 1999. Neuropsychopharmacol. 20, 255.
          Votey, S.R., et al. 1991. Ann. Emerg. Med. 20, 181.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2013 JSW
          SynonymsGABAA Receptor Antagonist, Flumazenil, Ro 15-1788
          DescriptionA competitive blocker of benzodiazepine activation of inhibitory GABAergic synpases (ID50 = 200 mg/kg/i.p). Binds to the benzodiazepine site of GABAA receptors. Enhances GABAA-receptor mediated currents and antagonizes the enhancing effects of benzodiapine agonist flurazepam. Exhibits fast association and dissociation from the benzodiazepine binding site. Permeates the blood brain barrier, however, the level of uptake may depend on efflux effects of p-glycogprotein transporter.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number78755-81-4
          Chemical formulaC₁₅H₁₄FN₃O₃
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (25 mM). Slight warming is required for complete solubilization.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesFroklage, F.E., et al. 2012. EJNMMI Research. 2, 12.
          Li, J., et al. 2006. Neuropharmacol. 51, 168.
          Weiss, M., et al. 2002. Neurochem. Res. 27, 1605.
          Atack, J., et al. 1999. Neuropsychopharmacol. 20, 255.
          Votey, S.R., et al. 1991. Ann. Emerg. Med. 20, 181.