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341280 Factor I, Human

Factor I, Human, is a glycoprotein composed of two non-identical disulfide-bonded subunits of 50 and 38 kDa. A serine protease that requires protein cofactor in order to effect substrate cleavage.

Factor I, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: C3b/C4b Inactivator

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341280
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341280-250UG
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      		 Plastic ampoule 250 μg
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      Description
      OverviewNative factor I from human serum. Glycoprotein composed of two non-identical disulfide-bonded subunits of M.W. of 50 kDa (α) and 38 kDa (β). Present in normal human serum at about 34 µg/ml. A serine protease that requires protein cofactor in order to effect substrate cleavage. Thus, either Factor H or Factor I mediates cleavage of C3b. C4-binding protein or complement receptor CR1 can function as the cofactor required for Factor I-mediated cleavage of C4b.
      Catalogue Number341280
      Brand Family Calbiochem®
      SynonymsC3b/C4b Inactivator
      References
      ReferencesSolol-Celigny, P., et al. 1982. Clin. Exp. Immunol. 47, 197.
      Pangburn, M.K., et al. 1977. J. Exp. Med. 146, 257.
      Product Information
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsIgG, IgA, IgM, Factor H, Factor B, Factor P, C3, C4, or albumin: ≤trace amounts
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      341280-250UG 04055977215588

      Documentation

      Factor I, Human SDS

      Title

      Safety Data Sheet (SDS) 

      Factor I, Human Certificates of Analysis

      TitleLot Number
      341280

      References

      Reference overview
      Solol-Celigny, P., et al. 1982. Clin. Exp. Immunol. 47, 197.
      Pangburn, M.K., et al. 1977. J. Exp. Med. 146, 257.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-June-2008 RFH
      SynonymsC3b/C4b Inactivator
      DescriptionNative factor I from human serum. Glycoprotein composed of two non-identical disulfide-bonded subunits of M.W. of ~50 kDa (α) and ~38 kDa (β). Present in normal human serum at about 34 µg/ml. A serine protease that requires protein cofactor in order to effect substrate cleavage. Either Factor H or Factor I mediates cleavage of C3b. C4-binding protein or complement receptor CR1 can function as the cofactor required for Factor I mediated cleavage of C4b.
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥95% by SDS-PAGE
      ContaminantsIgG, IgA, IgM, Factor H, Factor B, Factor P, C3, C4, or albumin: ≤trace amounts
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesSolol-Celigny, P., et al. 1982. Clin. Exp. Immunol. 47, 197.
      Pangburn, M.K., et al. 1977. J. Exp. Med. 146, 257.