341262 Factor B, Human

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341262
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341262-250UG
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      Plastic ampoule 250 μg
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      Description
      OverviewNative factor B from human serum. Single-chain glycoprotein present in normal human serum at about 200 µg/ml. During activation of complement via the alternative pathway, Factor B is cleaved and thus activated by Factor D into two fragments of M.W. of 30 kDa (Ba) and 63 kDa (Bb). The Bb fragment contains the serine protease enzymatic active site. The activated Bb fragment continues activation via the alternative pathway by cleaving, and thus activating, C3 and C5.
      Catalogue Number341262
      Brand Family Calbiochem®
      SynonymsC3 Proactivator
      References
      ReferencesKam, C.M., et al. 1987. J. Biol. Chem. 262, 3444.
      Gotze, O. and Muller-Eberhard, H.J. 1971. J. Exp. Med. 134, 90s.
      Product Information
      FormLiquid
      FormulationIn PBS, pH 7.2.
      Applications
      Biological Information
      Biological activity≥1,200 Factor BH50 units/mg; ≥50% of Factor B activity in NHS (mg/mg basis)
      Purity≥90% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Physicochemical Information
      ContaminantsIgG, IgA, IgM, C3, C4, Factor H, Factor I, or albumin (Ouchterlony): ≤trace amounts
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Factor B, Human Certificates of Analysis

      TitleLot Number
      341262

      References

      Reference overview
      Kam, C.M., et al. 1987. J. Biol. Chem. 262, 3444.
      Gotze, O. and Muller-Eberhard, H.J. 1971. J. Exp. Med. 134, 90s.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-June-2008 RFH
      SynonymsC3 Proactivator
      DescriptionNative factor B from human serum. Single-chain glycoprotein present in normal human serum at about 200 µg/ml. During activation of complement via the alternative pathway, Factor B is cleaved, and thus activated by Factor D into two fragments of M.W. of ~30 kDa (Ba) and ~63 kDa (Bb). The Bb fragment contains the serine protease enzymatic active site. The activated Bb fragment continues activation via the alternative pathway by cleaving, and thus activating, C3 and C5.
      FormLiquid
      FormulationIn PBS, pH 7.2.
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥90% by SDS-PAGE
      ContaminantsIgG, IgA, IgM, C3, C4, Factor H, Factor I, or albumin (Ouchterlony): ≤trace amounts
      Biological activity≥1,200 Factor BH50 units/mg; ≥50% of Factor B activity in NHS (mg/mg basis)
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesKam, C.M., et al. 1987. J. Biol. Chem. 262, 3444.
      Gotze, O. and Muller-Eberhard, H.J. 1971. J. Exp. Med. 134, 90s.