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341253 FAAH Inhibitor III, URB937 - Calbiochem

FAAH Inhibitor III, URB937 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Cyclohexylcarbamic acid-(3ʹ–carbamoyl–6–hydroxybiphenyl–3–yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoylhydroxybiphenyl–3–yl)ester

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      Overview

      Replacement Information
      Description
      OverviewA blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8 nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100 µM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2 mg/kg vs. 40 mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1 mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available (Cat. No. 341249).
      Catalogue Number341253
      Brand Family Calbiochem®
      SynonymsCyclohexylcarbamic acid-(3ʹ–carbamoyl–6–hydroxybiphenyl–3–yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoylhydroxybiphenyl–3–yl)ester
      References
      ReferencesClapper, J.R., et al. 2010. Nat. Neurosci. 13, 1265.
      Product Information
      FormGrey-white powder
      Hill FormulaC₂₀H₂₂N₂O₄
      Chemical formulaC₂₀H₂₂N₂O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      341253

      Documentation

      FAAH Inhibitor III, URB937 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Clapper, J.R., et al. 2010. Nat. Neurosci. 13, 1265.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-May-2013 JSW
      SynonymsCyclohexylcarbamic acid-(3ʹ–carbamoyl–6–hydroxybiphenyl–3–yl)ester, Fatty Acid Amide Hydrolase Inhibitor III, URB937, Cyclohexylcarbamic acid-carbamoylhydroxybiphenyl–3–yl)ester
      DescriptionA blood-brain-barrier impermeable p-hydroxyphenylcarbamate compound that acts as a potent and irreversible inhibitor of FAAH activity (IC50 = 26.8 nM rat brain) with excellent selectivity over monoacylglycerol lipases (IC50 > 100 µM). Shown to rapidly block mouse liver FAAH activity over brain (ED50 = 0.2 mg/kg vs. 40 mg/kg, s.c.), elevate anandamide and palmitoylethanolamide levels in peripheral tissues (1 mg/kg, i.p.) and exert antinociceptive action. The CNS-penetrant FAAH Inhibitor II, URB597 is also available (Cat. No. 341249).
      FormGrey-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₂₂N₂O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesClapper, J.R., et al. 2010. Nat. Neurosci. 13, 1265.