341216 Ezrin Inhibitor, NSC668394 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₇H₁₂Br₂N₂O₃

Pricing & Availability

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341216-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, quinoline that binds directly to ezrin (Kd = 12.6 µM) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50 = 8.1 µM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 µM. At 10 µM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10 µM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vivo at 2.26 mg/kg/day.
      Catalogue Number341216
      Brand Family Calbiochem®
      Synonyms7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione
      References
      ReferencesBulut, G., et al. 2011. Oncogene 31, 269.
      Product Information
      FormReddish orange solid
      Hill FormulaC₁₇H₁₂Br₂N₂O₃
      Chemical formulaC₁₇H₁₂Br₂N₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ezrin Inhibitor, NSC668394 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ezrin Inhibitor, NSC668394 - Calbiochem Certificates of Analysis

      TitleLot Number
      341216

      References

      Reference overview
      Bulut, G., et al. 2011. Oncogene 31, 269.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2012 JSW
      Synonyms7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione
      DescriptionA cell-permeable, quinoline that binds directly to ezrin (Kd = 12.6 µM) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50 = 8.1 µM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 µM. At 10 µM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10 µM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vivo at 2.26 mg/kg/day.
      FormReddish orange solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₂Br₂N₂O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml; clear, red-orange solution)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBulut, G., et al. 2011. Oncogene 31, 269.