Pricing & Availability
An invalid quantity was specified. The product quantity has been adjusted.
|374096-50UG||Plastic ampoule||50 μg||
|Overview||Native, human eosinophil peroxidase. Eosinophil peroxidase is a secreted hemoprotein that catalyzes oxidations of various substrates by hydrogen peroxide. Together with other leukocyte-derived enzymes, such as Myeloperoxidase (Cat. No. 475911), EPO plays an important role in the pathogenesis of asthma by mediating oxidative events that lead to the production of ROS (reactive oxygen species) and RNS (reactive nitrogen species).|
|Unit of Definition||One unit is defined as the amount of enzyme that will cause an increase in absorbance of 1 at 470 nm per min at pH 7.0 and 25°C, calculated from the initial linear rate of reaction using guaiacol as substrate.|
|Formulation||Lyophilized from 5 mM phosphate buffer, pH 7.0.|
|Purity||≥90% by SDS-PAGE|
|Source||Prepared from tissue that has been shown by certified tests to be negative for HBsAg and for antibodies to HCV and HIV.|
|Specific Activity||≥ 270 units/mg protein (Guaiacol Assay Method)|
|Safety Information according to GHS|
|Product Usage Statements|
Eosinophil Peroxidase, Human SDS
|Andreadis., et al. 2003. Free Radic. Biol. Med. 35, 213.
Borelli, V., et al. 2003. Infect. Immun. 71, 605.
Erpenbeck, V.J., et al. 2003. Clin. Exp. Allergy 33, 331.
McElhinney, B., et al. 2003. J. Leukoc. Biol. 74, 897.
Aldridge, R.E., et al. 2002. Free Radic. Biol. Med. 33, 847.
Kettle, A.J., and Winterbourn, C.C. 1988. Biochim. Biophys. Acta 957, 185.
Desser, R.K., et al. 1972. Arch. Biochem. Biophys. 148, 452.
Hager, L.P., et al. 1966. J. Biol. Chem. 241, 1769.