532089 Dual DYRK/CLK inhibitor, Cpd 23 - Calbiochem

532089
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₀H₈O₂S

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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable 5-hydroxybenzothiophenylethanone that acts as a dual inhibitor of Cdc2-like kinase 1 (Clk1; IC50 = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC50 = 200 and 100 nM, respectively). Also inhibits Clk4 with high potency. Exhibits much reduced inhibitory effect on Haspin ( IC50 = 800 nM) and has much reduced inhibitory effect on other kinases even at higher concentration (~ 5 µM). Causes a complete disappearance of incomplete and alternatively spliced transcripts and is shown to enhance the generation of the mature Clk1 mRNA splicing product (EC50 = 8.9 µM) in cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number532089
      Brand Family Calbiochem®
      SynonymsPre-mRNA Splicing Modulator, DYRK Inhibitor, Cdc2-like Kinase Inhibitor
      References
      ReferencesSchmitt, C., et al. 2014. ACS Med. Chem. Lett. 5, 963.
      Product Information
      FormYellow powder
      Hill FormulaC₁₀H₈O₂S
      Chemical formulaC₁₀H₈O₂S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDYRK/CLK
      Primary Target IC<sub>50</sub>60 nM, EC₅₀
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Dual DYRK/CLK inhibitor, Cpd 23 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Schmitt, C., et al. 2014. ACS Med. Chem. Lett. 5, 963.

      Technical Info

      Title
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      White Paper: Further considerations of antibody validation and usage. (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-March-2015 JSW
      SynonymsPre-mRNA Splicing Modulator, DYRK Inhibitor, Cdc2-like Kinase Inhibitor
      DescriptionA cell permeable 5-hydroxybenzothiophenylethanone that acts as a dual inhibitor of Cdc2-like kinase 1 (Clk1; IC50 = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC50 = 200 and 100 nM, respectively). Also inhibits Clk4 with high potency. Exhibits much reduced inhibitory effect on Haspin ( IC50 = 800 nM) and has much reduced inhibitory effect on other kinases even at higher concentration (~ 5 µM). Causes a complete disappearance of incomplete and alternatively spliced transcripts and is shown to enhance the generation of the mature Clk1 mRNA splicing product (EC50 = 8.9 µM) in cells.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₀H₈O₂S
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchmitt, C., et al. 2014. ACS Med. Chem. Lett. 5, 963.