Product Information
Applications
Biological Information
Primary TargetDHODH
Primary Target IC<sub>50</sub>12 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Dihydroorotate Dehydrogenase Inhibitor, Brequinar - CAS 96201-88-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
He, T. et al. 2013. Oncogene 32, in press.
Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1610.
Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents. 38, 435.
Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett. 14, 1549.
Allison, A., et al. 1993. Transplantation Proc. 25, 67.
Cramer, D. et al. 1992. Transplantation. 53, 303.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-January-2014 JSW
Synonyms6-fluoro-2-(2ʹ-fluoro-1,1ʹ-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785
DescriptionA quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number96201-88-6
Chemical formulaC₂₃H₁₄F₂NNaO₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHe, T. et al. 2013. Oncogene 32, in press.
Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1610.
Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents. 38, 435.
Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett. 14, 1549.
Allison, A., et al. 1993. Transplantation Proc. 25, 67.
Cramer, D. et al. 1992. Transplantation. 53, 303.

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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Immunomodulators