Product Information
Applications
Biological Information
Physicochemical Information
Boiling point40 °C (1013 hPa)
Density1.33 g/cm3 (20 °C)
Evaporation number1.9
Explosion limit13 - 22 %(V)
Ignition temperature605 °C DIN 51794
Melting Point-95 °C
Vapor pressure475 hPa (20 °C)
Solubility20 g/l
Dimensions
Materials Information
Toxicological Information
LD 50 oralLD50 Rat 1600 mg/kg
LD 50 dermalLD50 Rat > 2000 mg/kg
Safety Information according to GHS
Hazard Pictogram(s) Hazard Pictogram(s)
Hazard Pictogram(s)
Hazard Statement(s)H315: Causes skin irritation.
H319: Causes serious eye irritation.
H336: May cause drowsiness or dizziness.
H351: Suspected of causing cancer.
Precautionary Statement(s)P281: Use personal protective equipment as required.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308 + P313: IF exposed or concerned: Get medical advice/ attention.
Signal WordWarning
RTECSPA8050000
Storage class6.1 D Non combustible, acute toxicity cat. 3 / toxic or substances with chronic effects
WGKWGK 2 obviously hazardous to water
Disposal2
Organic halogenated solvents and solutions of organic halogen-containing substances: For strongly contaminated or mixed halogenated solvents container B: Caution: Do not use aluminium containers; in addition, in the case of water-containing chlorinated waste materials do not use stainless-steel containers (danger of leaks caused by corrosion).
Safety Information
Hazard Symbols Hazard SymbolsHarmful
Categories of dangercarcinogenic
R PhraseR 40
Limited evidence of a carcinogenic effect.
S PhraseS 3-36/37
Keep in a cool place.Wear suitable protective clothing and gloves.
Product Usage Statements
Storage and Shipping Information
StorageStore at +15°C to +25°C.
Packaging Information
Transport Information
Declaration (railroad and road) ADR, RIDUN 1593 , 6.1, III
Declaration (transport by air) IATA-DGRUN 1593 , 6.1, III
Declaration (transport by sea) IMDG-CodeUN 1593 , 6.1, III, Segregation Group: 10 (Liquid halogenated hydrocarbons)
Supplemental Information
Specifications
Purity (GC)≥ 99.0 %
Identity (IR)conforms
Appearance of the substanceconforms
Acidic substancesconforms
Acidity (HCl)≤ 0.001 %
Density (d 20 °C/20 °C)1.320 - 1.332
Density (d 25 °C/25 °C)1.318 - 1.322
Refractive index (n 20/D)1.423 - 1.425
Free chlorine (Cl)conforms
Ethanol,2-Methyl-2-butene and volatile impurities (GC) (Ethanol)≤ 2.0 % (v/v)
Ethanol,2-Methyl-2-butene and volatile impurities (GC) (2-Methyl-2-buten)≤ 0.03 % (v/v)
Ethanol,2-Methyl-2-butene and volatile impurities (GC) (Carbon tetrachloride (impurity A))≤ 0.001 % (v/v)
Ethanol,2-Methyl-2-butene and volatile impurities (GC) (Chloroform (impurity B))≤ 0.005 % (v/v)
Ethanol,2-Methyl-2-butene and volatile impurities (GC) (Total of impurities other than ethanol and 2-methyl-2-butene)≤ 0.1 % (v/v)
Ethanol,2-Methyl-2-butene and volatile impurities (GC)(reportingthreshold)≤ 0.005 % (v/v)
1,1-Dichloroethene (GC)≤ 0.03 %
1,2-Dichloroethene (GC)≤ 0.03 %
Other residual solvents (ICH Q3C)excluded by manufacturing process
Evaporation residue≤ 0.002 %
Water≤ 0.020 %
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).
Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
The product is stabilized with about 50 ppm 2-Methyl-2-butene.
Conforms to Ph Eur, BP, NF.

Documentation

Material Qualification Dossier

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Quality Management Dossier

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Operational Excellence Dossier

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Dichloromethane SDS

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Safety Data Sheet (SDS) 

Dichloromethane Certificates of Analysis

Product Number PackagingSpecificationLot Number
1060492500 Glass bottlePDF Specification Document
1.06049.6010 Drum stainl. st.PDF Specification Document
1.06049.6025 Drum stainl. st.PDF Specification Document
1060496190 Drum stainl. st.PDF Specification Document
1060499190 Steel barrelPDF Specification Document

Certificates

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Categories

Biopharmaceutical Manufacturing > Formulation > Liquid Dosage > Solvents
Small Molecule Pharmaceuticals > Formulation > Liquid Dosage Form > Solvents