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252750 Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem

Parenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Desferrioxamine Mesylate, DFOM, Iron Chelator II

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252750
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
138-14-7C₂₅H₄₈N₆O₈·CH₄O₃S

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      Description
      OverviewParenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows anti-proliferative effect on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic acid moieties with trans-peroxynitrous acid.
      Catalogue Number252750
      Brand Family Calbiochem®
      SynonymsDesferrioxamine Mesylate, DFOM, Iron Chelator II
      References
      ReferencesBergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
      Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
      Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
      Dzwigaj, S., and pererat, H., 1995. Free Radic. Res. 14, 103.
      Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
      Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.
      Product Information
      CAS number138-14-7
      FormFaint yellow powder
      Hill FormulaC₂₅H₄₈N₆O₈·CH₄O₃S
      Chemical formulaC₂₅H₄₈N₆O₈·CH₄O₃S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity92.5-100% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUG5310000
      Safety Information
      R PhraseR: 22-36/37/38-40-42/43

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      Limited evidence of a carcinogenic effect.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      252750

      References

      Reference overview
      Bergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
      Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
      Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
      Dzwigaj, S., and pererat, H., 1995. Free Radic. Res. 14, 103.
      Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
      Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2008 RFH
      SynonymsDesferrioxamine Mesylate, DFOM, Iron Chelator II
      DescriptionParenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows antiproliferative effects on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic moieties with trans-peroxynitrous acid.
      FormFaint yellow powder
      CAS number138-14-7
      RTECSUG5310000
      Chemical formulaC₂₅H₄₈N₆O₈·CH₄O₃S
      Structure formulaStructure formula
      Purity92.5-100% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 2860
      ReferencesBergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.
      Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.
      Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.
      Dzwigaj, S., and pererat, H., 1995. Free Radic. Res. 14, 103.
      Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.
      Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.