454863 D-erythro-MAPP - CAS 143492-38-0 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₃H₃₉NO₂ 143492-38-0

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454863-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA synthetic analog of ceramide. Shown to selectively inhibit alkaline ceramidase both in vitro and in HL-60 cells (IC50 = 1-5 µM for alkaline ceramidase versus IC50 > 500 µM for acid ceramidase). This inhibition results in over 3-fold increase in endogenous ceramide in treated cells due to lack of breakdown of ceramide to sphingosine.
      Catalogue Number454863
      Brand Family Calbiochem®
      Synonyms(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP
      References
      ReferencesBielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
      Hannun, Y.A. 1996. Science 274, 1855.
      Product Information
      CAS number143492-38-0
      ATP CompetitiveN
      FormSolid
      Hill FormulaC₂₃H₃₉NO₂
      Chemical formulaC₂₃H₃₉NO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAlkaline ceramidase
      Primary Target IC<sub>50</sub>1-5 µM for alkaline ceramidase versus > 500 µM for acid ceramidase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      D-erythro-MAPP - CAS 143492-38-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      D-erythro-MAPP - CAS 143492-38-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      454863

      References

      Reference overview
      Bielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
      Hannun, Y.A. 1996. Science 274, 1855.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-September-2019 JSW
      Synonyms(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP
      DescriptionA synthetic analog of ceramide. Shown to selectively inhibit alkaline ceraminidase both in vitro and in HL-60 cells (IC50 = 1-5 µM for alkaline ceramides versus IC50 >500 µM for acid ceraminidase). This inhibition results in and over 3-fold increase in endogenous ceramide in treated cells due to a lack of breakdown of ceramide to sphingosine.
      FormSolid
      CAS number143492-38-0
      Chemical formulaC₂₃H₃₉NO₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityEthanol (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesBielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
      Hannun, Y.A. 1996. Science 274, 1855.