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101641 Congo Red staining kit

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      Catalogue Number101641
      DescriptionCongo Red staining kit
      OverviewThe Congo Red staining kit - Kit for the detection of amyloid acc. to Highman, is used for human-medical cell diagnosis and serves the purpose of the histological investigation of sample material of human origin for example histological sections of e. g. the kidney, the intestine, or the liver.
      This Congo red staining kit contains all the reagents necessary for staining amyloid in histological tissues. Amyloid is a homogenous structure made up of protein fibrils (each between 8 and 15 nm in diameter) that can be stained eosinophilically, which e. g. in the case of amyloidosis forms deposits in the intercellular space. All deposits of amyloid contain similar protein fibrils that are resistant to the body’s natural defence mechanisms and that once they have formed cannot be eliminated.The Congo red staining principle is based on the formation of hydrogen bridge bonds with the carbohydrate component of the substrate. Congo red is an anionic dye and is capable of depositing itself in amyloid fibrils, which then exhibit a conspicuous dichroism under polarized light. The tissue stained with Congo red appears orange-red under the transmitted-light microscope; under polarized light, however, the amyloid deposits show up as brilliant green double-refraction images against a dark background. Other structures also stained by Congo red, e. g. collagen, however are not visualized under polarized light. Staining may be technically difficult when the paraffin sections used are too thin (<5 μm) or when the tissue is too strongly over-stained.
      The kit is sufficient for up to 50 applications. This product is registered as IVD and CE marked. For more details, please see instructions for use (IFU). The IFU can be downloaded from this webpage.
      Product Information
      HS Code3212 90 00
      Quality LevelMQ400
      ApplicationKit for detection of amyloid acc. to Highman
      Biological Information
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Hazard Pictogram(s) Hazard Pictogram(s)
      Hazard Pictogram(s)
      Hazard Pictogram(s)
      Hazard Statement(s)H225: Highly flammable liquid and vapour.
      H290: May be corrosive to metals.
      H315: Causes skin irritation.
      H319: Causes serious eye irritation.
      H350: May cause cancer.
      Precautionary Statement(s)P202: Do not handle until all safety precautions have been read and understood.
      P210: Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
      P233: Keep container tightly closed.
      P303 + P361 + P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
      P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
      P308 + P313: IF exposed or concerned: Get medical advice/ attention.
      P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
      Signal WordDanger
      Storage class3 Flammable liquids
      WGKWGK 3 highly hazardous to water
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      StorageStore at +15°C to +25°C.
      Packaging Information
      Transport Information
      Declaration (railroad and road) ADR, RIDUN 3316 Chemie-Testsatz, 9, II
      Declaration (transport by air) IATA-DGRUN 3316 CHEMICAL KIT, 9, II
      Declaration (transport by sea) IMDG-CodeUN 3316 CHEMICAL KIT, 9, II
      Supplemental Information
      Suitability for microscopypasses test
      Amyloidpink to red; in polarized ligt green metachromasis
      Nucleidark blue
      Connective tissuelight red

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