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500112 Cocarboxylase chloride

Overview

Replacement Information

Key Specifications Table

CAS #EC NumberHill FormulaMolar Mass
154-87-0205-836-1C₁₂H₁₉ClN₄O₇P₂S460.80 g/mol

Pricing & Availability

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      5001121000
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          5001125000
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              Description
              Catalogue Number500112
              SynonymsThiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
              References
              Product Information
              CAS number154-87-0
              EC number205-836-1
              Hill FormulaC₁₂H₁₉ClN₄O₇P₂S
              Molar Mass460.80 g/mol
              HS Code2936 22 00
              Structure formula ImageStructure formula Image
              Quality LevelMQ600
              Applications
              Biological Information
              Physicochemical Information
              Melting Point240 - 244 °C (decomposition)
              pH value2.2 (H₂O)
              Bulk density500 kg/m3
              Solubility220 g/l
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSXI7552000
              Storage class10 - 13 Other liquids and solids
              WGKWGK 3 highly hazardous to water
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at +2°C to +25°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Assay (HPLC, calc. on dried substance)≥ 93.0 %
              Appearance (color)white
              Appearance (description)crystalline powder
              Identity (IR-spectrum)conforms
              Identity (Cl)passes test
              Appearance of solution (10 %; water)clear,< colour reference solution Y7
              pH-value (10 %; water)1.0 - 1.4
              Chloride (Cl) (calculated on dried substance)7.5 - 7.9 %
              Free phosphate (PO₄)≤ 1.0 %
              Sulfate (SO₄)≤ 0.01 %
              Al (Aluminium) (#)≤ 0.0010 %
              As (Arsenic)≤ 0.0003 %
              Ni (Nickel) (#)≤ 0.0002 %
              Thiamin Monophosphoric Acid Ester Chloride (HPLC)≤ 4.0 %
              Thiamin Dichloride (HPLC)≤ 0.5 %
              Dithiamintriphosphate (HPLC)≤ 0.20 %
              Impurity A (HPLC)≤ 0.1
              Impurity B (HPLC)≤ 0.1
              Related substances (HPLC)≤ 1.5 %
              Loss on drying (130 °C)≤ 1.5 %
              Endotoxins≤ 12 I.U./g
              Microbiological testpasses test
              Colony count (aerobic bacteria (TAMC))≤ 500 CFU/g
              Colony count (Yeasts and moulds (TYMC))≤ 100 CFU/g
              Salmonella speciesIn 10g substance not detectable
              E.coliIn 1g substance not detectable
              Staphylococcus aureusIn 1g substance not detectable
              Pseudomonas aeruginosaIn 1g substance not detectable
              Candida albicansIn 1g substance not detectable
              Residual solvents (Ph Eur/USP/ICH) class 2 (Methanol)≤ 2.0 %
              Other residual solvents (Ph Eur/USP/ICH)excluded by manufacturing process
              Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).
              Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (#).
              Residues of metal or metal reagents acc. to EMEA/CHMP/SWP/ 4446/2000 are not likely to be present.

              Documentation

              Elemental Impurities Information

              Title

              Cocarboxylase chloride SDS

              Title

              Safety Data Sheet (SDS) 

              Cocarboxylase chloride Certificates of Analysis

              Product Number PackagingSpecificationLot Number
              5001120100 Plastic bottlePDF Specification Document
              5001121000 Plastic bottlePDF Specification Document
              5001125000 Plastic bottlePDF Specification Document

              Certificates

              Title
              Halal Certificate for 500112 Cocarboxylase (chloride) thiamine diphosphoric acid ester chloride EMPROVE®
              Kosher Certificate 500112 Cocarboxylase (chloride) thiamine diphosphoric acid ester chloride, suitable for use as active pharmaceutical ingredient EMPROVE®

              Brochure

              Title
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