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220320 Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₃₁H₃₀N₆O₆S₄ 1403-36-7

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220320-1MG
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      Description
      OverviewA cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation, and prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and < 10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Does not affect the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.
      Catalogue Number220320
      Brand Family Calbiochem®
      SynonymsCS-1, CTM
      References
      ReferencesFujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
      Kung, A.L., et al. 2004. Cancer Cell 6, 33.
      Product Information
      CAS number1403-36-7
      FormOff-white solid
      Hill FormulaC₃₁H₃₀N₆O₆S₄
      Chemical formulaC₃₁H₃₀N₆O₆S₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSFM3038000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      220320

      References

      Reference overview
      Fujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
      Kung, A.L., et al. 2004. Cancer Cell 6, 33.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-June-2009 RFH
      SynonymsCS-1, CTM
      DescriptionA cell-permeable antimicrobial that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation. Prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and <10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Exhibits no effect on the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1403-36-7
      RTECSFM3038000
      Chemical formulaC₃₁H₃₀N₆O₆S₄
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesFujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
      Kung, A.L., et al. 2004. Cancer Cell 6, 33.