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Description
Overview
A cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation, and prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and < 10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Does not affect the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.
Catalogue Number
220320
Brand Family
Calbiochem®
Synonyms
CS-1, CTM
References
References
Fujimoto, H., et al. 2004. J. Nat. Prod.67, 98. Kung, A.L., et al. 2004. Cancer Cell6, 33.
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Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Documentation
Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem SDS
Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem Certificates of Analysis
Title
Lot Number
220320
References
Reference overview
Fujimoto, H., et al. 2004. J. Nat. Prod.67, 98. Kung, A.L., et al. 2004. Cancer Cell6, 33.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
25-June-2009 RFH
Synonyms
CS-1, CTM
Description
A cell-permeable antimicrobial that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation. Prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and <10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Exhibits no effect on the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.
Form
Off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
1403-36-7
RTECS
FM3038000
Chemical formula
C₃₁H₃₀N₆O₆S₄
Structure formula
Purity
≥97% by HPLC
Solubility
DMSO (5 mg/ml)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C.
Toxicity
Toxic
References
Fujimoto, H., et al. 2004. J. Nat. Prod.67, 98. Kung, A.L., et al. 2004. Cancer Cell6, 33.
