219489 Ceramide Kinase Inhibitor, K1

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₁H₂₈O₄ 1258005-85-4

Pricing & Availability

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219489-1MG
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      Plastic ampoule 1 mg
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      Description
      Overview

      This product has been discontinued.



      A cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC50 = ~5 µM) with little effect against SPHK1/2 or DGKγ (IC50 > 100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥ 20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.

      Catalogue Number219489
      Brand Family Calbiochem®
      SynonymsF-12509A Cyclic Product K1
      References
      ReferencesKim, J.W., et al. 2007. Biochim. Biophys. Acta 1771, 1262.
      Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem. 71, 2581
      Kim, J.W., et al. 2005. Biochim. Biophys. Acta 1738, 82.
      Product Information
      CAS number1258005-85-4
      DeclarationSold for research purposes only, pursuant to an agreement with Japan.
      FormYellow powder
      Hill FormulaC₂₁H₂₈O₄
      Chemical formulaC₂₁H₂₈O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by NMR (mixture of enantiomers)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ceramide Kinase Inhibitor, K1 SDS

      Title

      Safety Data Sheet (SDS) 

      Ceramide Kinase Inhibitor, K1 Certificates of Analysis

      TitleLot Number
      219489

      References

      Reference overview
      Kim, J.W., et al. 2007. Biochim. Biophys. Acta 1771, 1262.
      Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem. 71, 2581
      Kim, J.W., et al. 2005. Biochim. Biophys. Acta 1738, 82.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      SynonymsF-12509A Cyclic Product K1
      DescriptionA cell-permeable tetracyclic quinone compound that acts as a specific, reversible, and non-competitive inhibitor of CerK (ceramide kinase) activity (IC50 ~5 µM) with little effect against SPHK1/2 or DGKγ (IC50 >100 µM). Shown to reduce cellular C1P (ceramide-1-phosphate) synthesis by 40% at ≥20 µM in a rat basophilic leukemia cell line RBL-2H3 and block CerK-mediated degranulation in both RBL-2H3 and murine BMMC (bone marrow-derived mast cells) in a dose-dependent manner. Exhibits no cytotoxic effect against RBL-2H3 even at concentrations as high as 100 µM.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1258005-85-4
      Chemical formulaC₂₁H₂₈O₄
      Structure formulaStructure formula
      Purity≥95% by NMR (mixture of enantiomers)
      SolubilityEthanol (20 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, J.W., et al. 2007. Biochim. Biophys. Acta 1771, 1262.
      Kumada, H., et al. 2007. Biosci. Biotechnol. Biochem. 71, 2581
      Kim, J.W., et al. 2005. Biochim. Biophys. Acta 1738, 82.